Dell Products Inc.

Hinova Pharmaceuticals Inc.

Fei Wang

Chen Gong

Ke Chen

Changxu Jiang

Shaohua Zhang

Yuanwei Chen

Xinghai Li

Wu Du

Lei Fan

Kexin Xu

Tongchuan Luo

Xiaoquan Wu

Yongxu Huo

Zhilin Tu

Chengzhi Zhang

An EP300/CBP inhibitor, specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.

EP300/CBP inhibitor

Techniques for data deduplication compress and deduplicate a first set of blocks written to a source system to obtain a second set of blocks and compression ratios and numbers of duplications for blocks in the second set of blocks. Such techniques receive a request to back up the first set of blocks. Such techniques reconstruct, in response to receiving the request to back up the first set of blocks, the second set of blocks to obtain the first set of blocks. Such techniques mark, based on the compression ratios and the numbers of duplications, blocks in the first set of blocks with deduplication flags to obtain a third set of blocks. Such techniques transmit the third set of blocks to a destination system.

Method, device, and computer program product for data deduplication

Techniques for de-duplicating data involve: determining a target physical block in a first storage device. The techniques further involve: determining a compression ratio of a target data block in a plurality of data blocks to be transferred. The techniques further involve: determining a target hash value of the target data block in response to the compression ratio being lower than a threshold compression ratio. The techniques further involve: determining a de-duplication operation for the target data block based on the target hash value and a de-duplication hash table, the de-duplication hash table storing hash values of data blocks that have been transferred from the first storage device to the second storage device. Accordingly, the amount of data that needs to be transferred can be reduced, and the storage space of the storage devices can be improved, thus increasing the resource utilization and improving the user experience.

Method, device, and computer program product for de-duplicating data

Techniques for transferring data involve: determining a first physical block in a first storage device, the first physical block having a plurality of data blocks stored thereon. The techniques further involve: determining, based on a first data block of the plurality of data blocks, whether a set of logically contiguous data blocks that comprise the first data block exist in the first physical block, the set of data blocks having a target heat greater than a threshold heat. The techniques further involve: transferring, in response to the existence of the set of data blocks in the first physical block, the set of data blocks into a second storage device for contiguous storage in a second physical block of the second storage device. Accordingly, relatively high heat data blocks are transferred to device with higher access speed, thereby reducing data access time, increasing data processing efficiency, and improving user experience.

Method, device and computer program product for transferring data

Techniques involve determining, in response to acquiring a target block size for a shared folder of a first file system in a file system set, a shared folder de-duplication rate. The techniques further involve acquiring a de-duplication block size set supported by a storage system set for the file system set in response to determining that the de-duplication rate is less than a threshold de-duplication rate. The techniques further involve determining whether the de-duplication block size set includes a de-duplication block size that is the same as the target block size. The techniques further involve migrating the shared folder to a second file system in response to the de-duplication block size set including the de-duplication block size that is the same as the target block size. Accordingly, there is improved efficiency in deleting duplicate data, increased amount of deleted duplicate data, saved storage space and improved resource utilization.

Method, device, and computer program product for processing data

The compound of formula (I) has a good inhibitory effect on the proliferation of human prostate cancer cells CWR22RV1 and breast cancer cells; and combined use of the compound with an androgen receptor inhibitor HC-1119 significantly enhances the inhibitory effect on prostate cancer cells, and the inhibitory effect increases with increased concentration. The compound of formula (I) can not only be used independently to prepare an antineoplastic agent but can also be used in combination with other agents having antineoplastic effects, such as an androgen receptor inhibitor, or other targeting drugs etc., to prepare an antineoplastic agent having stronger therapeutic effects, especially an agent for treating prostate cancer and breast cancer.

BRD4 inhibitor as well as a preparative method and use thereof

An apparatus comprises a processing device configured to maintain a deduplication data structure comprising sub-portions associated with different compression ratio ranges and having different numbers of data block identifiers. The processing device is also configured to identify a given data block identifier and a given compression ratio for a given data block to be stored, and to determine whether the given data block identifier is in a given one of the sub-portions having a given compression ratio range including the given compression ratio. The processing device is further configured, responsive to determining that the given data block identifier is not in the given sub-portion, to write the given data block to a physical space block of the storage system and, responsive to determining that the given data block identifier is in the given sub-portion, to increment a deduplication reference count for the given data block identifier.

Compression ratio-aware data deduplication

Techniques for cache management involve: determining respective elimination scores of a plurality of entries in a cache based at least in part on compression rates of data blocks corresponding to the plurality of entries, the elimination score being proportional to the compression rate; and removing, from the cache, at least one entry with a relatively low elimination score among the plurality of entries. Such techniques are able to optimize the retention and elimination strategies for entries in a cache, thus increasing payoffs for using the cache.

Growing community of inventors

Chengdu, China

Fei Wang