Anacor Pharmaceuticals, Inc.

Crystal Pharmatech Co., Ltd.

Crystal Pharmaceutical (suzhou) Co., Ltd.

Suzhou Pengxu Pharmatech Co., Ltd.

Crystal Pharmatech Inc.

Fei Lu

Yanfeng Zhang

Minhua Chen

Xiaoyu Zhang

Nan Xia

Chaohui Yang

Yu Li

Peng Wang

Zengqiang Si

Pixu Li

Deming Wei

Ying Jia

Hui Gao

Yuhao Chen

Heng Ge

Xuezai Zheng

Dongxian Liu

The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.

Crystal forms of crisaborole in free form and preparation method and use thereof

The present disclosure relates to a novel crystalline form of Galunisertib, processes for preparation and use thereof. The present disclosure also relates to a pharmaceutical composition comprises the novel crystalline form of Galunisertib and use of the novel crystalline form of Galunisertib and pharmaceutical composition for preparing drugs treating disease. The crystalline form of the present disclosure has good stability, solubility and hygroscopicity, which has significant value for future drug optimization and development. 

Galunisertib crystalline form, preparation method thereof and use thereof

The present disclosure relates to novel crystalline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy) [1,1&#x2032;-biphenyl]-3-carboxamide monophosphate, and process of preparation thereof. The crystalline form of the monophosphate of a compound of formula (I) has low hygroscopicity, is convenient to store, has better stability than that of diphosphonate in prior art, can avoid the risk of crystal transformation in the development and production of the drug. The preparation method is simple, has low cost, and has important value for further optimization and development of the drug. 

Crystaline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-Methyl-4'-(trifluoromethoxy) [1,1&#x2032;-biphenyl]-3-Methanamide  monophosphate, and process of preparation thereof

Crystalline Form I of ibrutinib, processes for its preparation, pharmaceutical compositions comprising the new Form, and use of Form I of ibrutinib for treating or delaying diseases or disorders related to activity of Bruton's tyrosine kinase (BTK) proteins are disclosed. The novel Form was characterized by X-ray powder diffraction, differential scanning calorimetry, and other techniques. It can be readily prepared and is suitable for use in the preparation of solid dosage forms.

Crystalline form I of ibrutinib

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Suzhou, China

Fei Lu