The Penn State Research Foundation

Other

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Trs Technologies, Inc.

Fei Li

Thomas R Shrout

Shujun Zhang

Wesley S Hackenberger

Jun Luo

Frank J Gonzalez

James B Mitchell

Kevin A Snook

Andrew D Patterson

Raffi Sahul

Cen Xie

Changtao Jiang

Shantu G Amin

Dhimant H Desai

Shantu Amin

Dhimant Desai

Dabin Lin

Long-Qing Chen

A relaxor-PT based piezoelectric crystal is disclosed, comprising the general formula of (PbM){[(M,M)(M,M)]Ti}O, wherein: M is a rare earth cation; Mis selected from the group consisting of Mg, Zn, Yb, Sc, and In; Mis Nb; Mis selected from the group consisting of Mg, Zn, Yb, Sc, In, and Zr; Mis Nbor Zr; 0&#x3c;x&#x2264;0.05; 0.02&#x3c;y&#x3c;0.7; and 0&#x2264;z&#x2264;1, provided that if either Mor Mis Zr, both Mand Mare Zr. A method for forming the relaxor-PT based piezoelectric crystal is disclosed, comprising pre-synthesizing precursor materials by calcining mixed oxides, mixing the precursor materials with single oxides and calcining to form a feeding material, and growing the relaxor-PT based piezoelectric crystal having the general formula of (PbM){[(M,M)(M,M)]Ti}Ofrom the feeding material by a Bridgman method.

Polar nanoregions engineered relaxor-PbTiOferroelectric crystals

Embodiments of the invention can be directed to controlling and/or engineering the size and/or volume of polar nanoregions (PNRs) of ferroelectric polycrystalline material systems. Some embodiments can achieved this via composition modifications to cause changes in the PNRs and/or local structure. Some embodiments can be used to control and/or engineer dielectric, piezoelectric, and/or electromechanical properties of polycrystalline materials. Controlling and/or engineering the PNRs may facilitate improvements to the dielectric, piezoelectric, and/or electromechanical properties of materials. Controlling and/or engineering the PNRs may further facilitate generating a piezoelectric material that may be useful for many different piezoelectric applications.

Perovskite relaxor-PBTI0based ferroelectric ceramics with ultrahigh dielectric and piezoelectric properties through polar nanoregions engineering

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R, R, R, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal. 

Inhibitors of the farnesoid x receptor and uses in medicine

The application is directed to piezoelectric single crystals having shear piezoelectric coefficients with enhanced temperature and/or electric field stability. These piezoelectric single crystal may be used, among other things, for vibration sensors as well as low frequency, compact sonar transducers with improved and/or enhanced performance.

Temperature and field stable relaxor-PT piezoelectric single crystals

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R, R, R, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least Cone compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal. 

Inhibitors of the farnesoid X receptor and uses in medicine

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State College, PA, United States of America

Fei Li