Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Medshine Discovery Inc.

Fei Hong

Juan Yu

Jinming Huang

Zhiliang Chen

Shuhui Chen

Tingting Yin

Jian Li

Zhifei Fu

Miaorong Luo

Jinxia Lin

Yichao Zhuang

Shicong Wang

Zhiyi Luo

Xuxin Li

Haiying He

Wentao Wu

Zhigan Jiang

Zhixiang Li

Jian Qin

Xiaoping Zheng

Jinxiang Zeng

Longhui Gao

Zhaoqiang Zhang

Wenliang Lan

Liju Wang

Huijun Yuan

Disclosed in the present invention are a crystal form of a TrkA inhibitor and a preparation method thereof, and an application thereof in preparation of drugs for treating diseases associated with pain, cancer, inflammation, neurodegenerative diseases, and certain infectious diseases.

Crystal form of pyrrolidinyl urea derivative and application thereof

A crystal form of a pyrazin-2(1H)-one compound and a preparation method therefor. The present invention specifically related to a compound of formula (II) and a preparation method for a crystal form of the compound. 

Crystal forms C and E of pyrazin-2(1H)-one compound and preparation method therefor

Provided are crystalline forms of pyrazine-2(1H)-ketone compound and a preparation method thereof; specifically disclosed are a method for preparing the compound of formula (II) and crystalline forms thereof. 

Crystalline form and B crystalline form of pyrazine-2(1H)-ketone compound and preparation method thereof

Disclosed are a crystal form (I) as an inhibitor of ACC1 and ACC2, a preparation method therefor, and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2. 

Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof

Disclosed is a total flavonoids extract ofKitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract ofKitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract ofKitam. reaches 80%-85%.

Total flavonoids extract ofKitam., preparation method therefor and use thereof for treating hyperuricemia

A total flavonoid extract fromKitam., comprising 80-85% of rutin. A preparation method comprises selecting a complex enzyme consisting of a specific composition and ratio of enzymes for enzymatic hydrolysis, extracting and concentrating by a macroporous resin, and separating and purifying by a macroporous resin. The extract has therapeutic effect on non-alcoholic fatty liver disease.

Total flavonoid extract fromKitam., preparation method thereof, and use of same in treating non-alcoholic fatty liver disease

A total flavonoid extract fromKitam., comprising, in weight percent, 80-85% of rutin. A method for preparing the total flavonoid extract fromKitam. comprises solvent extraction, complex enzymatic hydrolysis, and separation and purification by a macroporous resin. The total flavonoid extract fromKitam. is used to prepare a drug or health product related to alcoholic fatty liver disease.

Total flavonoid extract from Gynura formosana Kitam., preparation method thereof, and use of same in preparing drug or health product related to alcoholic fatty liver disease

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Fujian, China

Fei Hong