Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Jiangsu Kanion Pharmaceutical Co., Ltd.

Zhuhai United Laboratories Co., Ltd.

Fei Hao

Haiying He

Peng Li

Xiaolin Li

Jian Li

Shuhui Chen

Wang Shen

Wei Xiao

Zhi Luo

Zhenzhong Wang

Bailing Yang

Hualing Xiao

Zongbin Li

Zheng Kuan Wang

Chong Su

Zheng Wang

A crystal form (such as formula I) of a 2-methyl-2-propanol and amino-substituted aryl compound and a preparation method therefor. Also provided is an application of the crystal form in the preparation of a medicine for treating related diseases.

Crystal form of 2-methyl-2-propanol and amino-substituted aryl compound

The present invention falls within the field of pharmaceutical chemistry, and relates to a method for preparing a steroid derivative FXR agonist and relevant intermediates. In particular, the present invention relates to a method for preparing a compound of formula I, comprising reacting a compound of formula 8 with a compound of formula 9 to obtain a compound of formula 10, obtaining a compound of formula 11 from a reaction of the compound of formula 10, and obtaining the compound of formula I from a reaction of the compound of formula 11, as well as the intermediates used, the methods for preparing the intermediates and the use of the intermediates. The reaction conditions of the preparation method are mild, and some of the steps can convert multiple groups simultaneously, thereby effectively shortening the sequence of steps. The preparation method is suitable for industrialized production. 

Method for preparing steroid derivative FXR agonist

The present invention discloses a salt form, crystal form and intermediate of the compound 1, and preparation method thereof. 

Salt form and crystal form of 1,2,5-thiadiazolidin-1,1-dioxide, preparation method thereof and intermediate

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Shanghai, China

Fei Hao