Genethon

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie (Paris 6)

Association Institut De Myologie

Fedor Svinartchouk

Jérémy Rouillon

Jeremy Rouillon

Thomas Voit

Luis Garcia

Isabelle Richard

Jerome Poupiot

Jérôme Denard

Jérôme Poupiot

The invention relates to a method for prognosing, diagnosing, determining the risk, and monitoring the evolution of a muscular dystrophy. It also relates to a method for evaluating the efficacy of a treatment of a muscular dystrophy in a subject in need thereof.

Methods for diagnosing or monitoring muscular dystrophies

A method for the diagnosis, prognosis and therapeutic monitoring of muscular dystrophy, by detecting titin or one or more fragments of titin in a bodily fluid is provided.

Method for diagnosing muscular dystrophy

Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.

Methods of increasing efficiency of vector penetration of target tissue

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Villejuif, France

Fedor Svinartchouk