H. Lundbeck A/s

Merz Pharma Gmbh & Co Kgaa

Dipharma Francis S.r.l.

Federico Sbrogiò

Andrea Castellin

Jacopo Zanon

Markus Henrich

Herbert Koller

Poul Dahlberg Nielsen

Michael Pyerin

Rikke E Humble

Steen Sogaard

Giulio Volpe

Thomas Pittelkow

Simona Negura

Jacobo Zanon

Oscar Martini

Gergely Tasi

Francesco Ciardella

Pal Kocsan

Luca Gregori

Pál KOCSÁN

Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i):

Synthesis of 1-amino-1,3,3,5,5,-cyclohexane mesylate

Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram.

Intermediates for the preparation of citalopram and escitalopram

A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound. 

Process for the preparation of ziprasidone

A process for the preparation of citalopram of formula (I)in which a compound of formula (II)wherein Z is iodo, bromo, chloro or CF&#x2014;(CF)&#x2014;SO&#x2014;O&#x2014; n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process; the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof.

Process for the preparation of pure citalopram

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Montecchio Maggiore, Italy

Federico Sbrogiò