Polichem S.a.

Federico Mailland

Michela Legora

Stefania Gagliardi

Daniela Ceriani

Simone Del Sordo

Giuliana Iob

Emanuela Mura

Alessandra Consonni

Anna Bulgheroni

Francesco Scarci

Maurizio Caserini

Paolo Mascarucci

Stefano De Luigi Bruschi

Chitosan-based nail formulations are useful to treat nail inflammatory diseases such as psoriasis, atopic dermatitis and lichen planus. The chitosan is normally in the form of an amino-polysaccharide derivative, preferably water soluble, such as hydroxypropyl chitosan. The formulation may be a nail lacquer, a spray, a cream, an ointment, a gel, a lotion or a foam and may comprise chitosan, a chitosan derivative or a salt thereof in an amount from 0.1 to 25 wt. % with respect to the total weight of the formulation.

Use of chitosans for the treatment of nail inflammatory diseases

A topical antifungal composition for treating onychomycosis includes a terbinafine and/or a pharmaceutically acceptable salt thereof in an amount of from 9% to 11% by weight of the composition, a hydroxypropyl chitosan in an amount of from 0.1% to 0.6% by weight of the composition, water in an amount of from 10.0% to 40.0% by weight of the composition, and a C-Calkanol in an amount of from 60% to 80% by weight of the composition.

Topical antifungal composition for treating onychomycosis

The present invention is directed to the use of pidotimod, or a physiologically acceptable salt thereof, to treat irritable bowel syndrome. For the treatment of the present invention, pidotimod, or a physiologically acceptable salt thereof, may be administered either by oral route or rectally.

Use of pidotimod to treat irritable bowel syndrome

(R)-Nifuratel is disclosed together with its use as bactericide and bacteriostatic agent as well as the pharmaceutical compositions containing the same; (R)-nifuratel has been surprisingly found to possess a better antimicrobial profile than either nifuratel racemate or (S)-nifuratel. A new procedure for the synthesis of both (R)-Nifuratel and (S)-Nifuratel is also disclosed.

(R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel

The present invention is directed to the use of chitosan, a chitosan derivative or a physiologically acceptable salt thereof, to increase nail growth rate. The invention is further directed to the use of chitosans to accelerate nail growth rate during treatment of nail illnesses, nail dystrophy or other nail conditions, in order to shorten considerably the specific treatments of said nail illnesses, nail dystrophy or other nail conditions.

Use of chitosans to increase nail growth rate

Compositions for improving the elasticity of the vagina and of the perineum during the last trimester of pregnancy, include combining a thiolated compound or mixture thereof with an ester of organic acid or mixture thereof. The compositions according to the present invention improve the elastic properties of the vaginal and/or perineal tissues in terms both of increased extensibility and faster elastic recovery. The compositions according to the present invention may decrease risk of trauma of perineal tissues during delivery, as well as risk of rectal or bladder incontinence as a post-partum short/medium/long term complication.

Compositions with enhanced elasticizing activity

A nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents, including a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Method of treating onychomycosis

The present invention is directed to compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, and a short-medium chain dicarboxylic acid amide, or a physiologically acceptable salt thereof, forming a film after application onto the skin, useful for protecting skin of the face and of other affected areas in couperose, rosacea and telangiectasia of the legs.

Compositions for treating rosacea

The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents

Chitosan-based nail formulations are useful to treat nail inflammatory diseases like psoriasis, atopic dermatitis and. The chitosan is normally in the form of an amino-polysaccharide derivative, preferably water soluble, such as hydroxypropyl chitosan. The formulation may be a nail lacquer, a spray, a cream, an ointment, a gel, a lotion or a foam and may have a content in chitosan, chitosan derivative or a salt thereof from 0.1 to 25 wt. % with respect to the total weight of the formulation.

A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5-40%, b) at least one cellulose ether in preferred amounts of 30-90% and c) at least one disintegrant in preferred amounts of 2-50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. According to a preferred embodiment, the matrix is used in amounts of about 5-60% and the active principle in amounts of about 2-70%, with respect to the weight of the formulation.

Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant in the manufacture of a medicament for treating female genital disorders

The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. Many of these compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives

New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed.  These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are also active againstspecies such asand

Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

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Lugano, Switzerland

Federico Mailland