Flamma S.p.a.

Reckitt Benckiser Calgon B.v.

Federico Della Negra

Renato Canevotti

Massimo Previtali

Antonietta Tomasulo

Stefano Maretto

Francesco Mormile

Liliana Oliva

Anna Rencurosi

Carla Baratta

Montserrat Riera

The present invention relates to a process for preparation of triazolo[4,5-d] pyrimidine cyclopentane compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention also provides novel compounds that can be used as intermediates in the process for preparing triazolo[4,5-d] pyrimidine cyclopentane compounds. The process and the intermediates are particularly useful for the preparation of ticagrelor and pharmaceutically acceptable salts thereof.

Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds

Gradual-release dosing device for at least one substance in a domestic-use apparatus comprises the presence of a water based work fluid, characterized in that it comprises a casing () within which a plurality of doses of said substances () is contained, necessary for the corresponding plurality of operation cycles of said apparatus. Said casing () being at least partly defined by a material perrreable to said work fluid and capable of releasing at least a dose of said substance () at each operation cycle of the apparatus. The substance comprises at least one washing-active, dishwashing-active or cleaning-active preparation from the group consisting of surfactants, builders, water softening agents, zeolites, silicates, polymers, carbonates, carboxylates, sulphonates, bleaching agents, bleach activators, bleach stabilizers, bleach catalysts, cobuilders, alkalizing agents, acidifying agents, redeposition inhibitors, dyes, fragrances, optical is brighteners, UV filters, fabric softeners, and rinse agents.

Gradual-release dosing device and seal of a domestic-use apparatus

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Padua, Italy

Federico Della Negra