Universität Autonoma De Barcelona

Universidad Autònoma De Barcelona

Laboratorios Del Dr. Esteve S.a.

Consejo Superior De Investigaciones Cientificas

Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Universidad De Alcalá De Henares

Universidad Autonoma De Barcelona-uab

Fátima Bosch Tubert

Verónica Jiménez Cenzano

Éduard Ayuso López

Albert Ruzo Matías

Eduard Ayuso López

David Callejas Castiñeiras

Eduard Ayuso

David Callejas Castiηeiras

Enrique J De La Rosa Cano

María Antonia Blasco Marhuenda

Bruno Bernardes

Patricia Boya Tremoleda

Maria Flora De Pablo Dávila

Silvia Corrochano Sánchez

Pedro De La Villa Polo

Rima Barhoum Tannous

The present invention relates to adeno-associated viral vector useful for transducing adipose tissue. The invention also relates to polynucleotides, plasmids, vectors and methods for the production of such adeno-associated viral vector. The invention also relates to gene therapy methods useful for the treatment of a disease that requires the regulation of the expression levels of a gene.

Adeno-associated viral (AAV) vectors useful for transducing adipose tissue

New gene therapy constructions and compositions are the subject of present invention. The gene therapy compositions consist in adeno-associated vectors which jointly express insulin (Ins) and glucokinase (Gck) genes. The new gene therapy constructions are useful for treatment of diabetes either in dogs or human beings.

Gene therapy composition for use in diabetes treatment

The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.

Vectors and sequences for the treatment of diseases

Growing community of inventors

Barcelona, Spain

Fátima Bosch Tubert