The Ohio State University

U.S. Borax, Inc.

Fazlul Alam

Werner Tjarks

Amit Patwardhan

Jun Li

Rolf F Barth

Abul K Anisuzzaman

Albert H Soloway

Gary Davis

Mahesh Patel

Terry Downing

There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.

2' and 3' Carboranyl uridines and their diethyl ether adducts

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Anaheim, CA, United States of America

Fazlul Alam