Synthon B.v.

Akzo Nobel N.v.

Faysal Kalmoua

Frans Van Dalen

Gerrit J B Ettema

Raymond J H Westheim

Raymond Westheim

Gerrit Jan Ettema

Richard Herman Woudenberg

Korinde Annemarie Jansen

Farid Abedin Dorkoosh

Raymond Jozef Hubertus Westheim

Lisa Karin Holmdahl

Crystalline aripiprazole Type II can be formulated into pharmaceutical tablets having reduced dissolution profile variability upon storage.

Pharmaceutical tablets of crystalline type II aripiprazole

Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.

Process of making crystalline type II aripiprazole

Alcoholates of aripiprazole are useful as pharmaceuticals and/or as intermediates in making aripiprazole Form A or Form B.

Crystalline aripiprazole solvates

Process of making crystalline Type II aripiprazole

Crystalline aripiprazole Form B can be formed by crystallizing from a solvent selected from 1-propanol, 2-propanol, 1-butanol, ethyl acetate, acetonitrile or a combination thereof.

Process of making crystalline aripiprazole

Process for preparing bisindenylalkanes

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Faysal Kalmoua