Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie (Paris 6)

Institut National Des Sciences Appliquees De Lyon

Université Claude Bernard Lyon I

Université Jean Monnet Saint-Étienne

Université Pierre Et Marie Curie

Inserm (institut National De La Sante Et De La Recherche Medicale)

Université Jean Monnet De Saint-etienne

Fatiha Nothias

Laurent David

Alexandra Montembault

Sylvia Soares

The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 &#x3bc;m (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses. It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.

Chitosan hydrogel for repairing nerve tissue

Growing community of inventors

Paris, France

Fatiha Nothias