Case Western Reserve University

University Hospitals Health System, Inc.

Uh Cleveland Medical Center

Faruk Orge

David L Wilson

Hao Wu

Juhwan Lee

Richard Helms

Tahseen Minhaz

A first set of embodiments relates to an apparatus comprising one or more processors configured to: access three-dimensional (3D) ultrasound imaging of an eye; generate at least one segmented ocular structure by segmenting at least one ocular structure represented in the 3D ultrasound imaging using at least one deep learning ocular structure segmentation model configured to generate a predicted segmentation volume of the at least one ocular structure based on at least one portion of the 3D ultrasound imaging; compute at least one clinical metric associated with the at least one segmented ocular structure based on the at least one segmented ocular structure; and display at least one of: the at least one segmented ocular structure, the at least one clinical metric, the 3D ultrasound imaging, or at least one portion of the 3D ultrasound imaging.

Processing three-dimensional (3D) ultrasound images

A bypass device can be implanted into a body tissue to provide fluid channels through the body tissue. The bypass device includes an open tubular base, and a plurality of pronged features attached to the open tubular base, the pronged features being reconfigurable from a first position to a second position. In the first position the pronged features extend longitudinally along a plane of the open tubular base, and the pronged features are reconfigurable to the second position by flexing the pronged features relative to the tubular base, such that in the second position the pronged features are configured for insertion through the body tissue. The pronged features may be configured as opposing arrow-shaped tangs that are flexed to form tent structures that are insertable through the body tissue. The bypass device may be used in a minimally invasive glaucoma surgery (MIGS) for treating glaucoma to define fluid flow channels that permit aqueous humor to pass through the trabecular meshwork and into Schlemm's canal.

Ocular device for treating glaucoma and related minimally invasive glaucoma surgery method

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Cleveland, OH, United States of America

Faruk Orge