Centre National De La Recherche Scientifique

Institut Pasteur

Institut National De La Sante Et De La Recherche Medicale

Université Paris Descartes

Other

Centre National De La Recherche Scientifique-cnrs

Universite Paris Cité

Inserm (institut National De La Sante Et De La Recherche Medicale)

Inserm

Farida Nato

Philippe J Sansonetti

Laurence Mulard

Armelle Phalipon

Françoise Baleux

Julien Boutet

Cyrille Grandjean

Catherine Guerreiro

Frédéric Belot

Frederic Belot

Pierre Chassagne

Francois Traincard

Shirley Longacre

Ronald Perraut

Hannah Polson

François Traincard

The present invention relates to a conjugate comprising an oligo- or polysaccharide selected from the group consisting of: (X)-{BCDA}-(Y)(X)-{CDAB}-(Y)(X)-{DABC}-(Y)(X)-{ABCD}n-(Y)wherein A, B, C, D, X and Y, x, y and n are as defined in claim, said oligo- or polysaccharide being bound to a carrier.

Glycoconjugates and their use as potential vaccines against infection by

The present invention relates to compounds derived from sugars which reproduce the epitopes ofserotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing ainfection using one or more oligosaccharides or polysaccharides or conjugates thereof.

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A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by

Accordingly, the invention provides constructs in which the nucleic acids encodingMSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.

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Antony, France

Farida Nato