Agency for Science, Technology and Research

Medical Research Council

454 Life Sciences Corporation

Farid Ghadessy

Phillip Holliger

Philipp Holliger

Peter Dröge

Harshyaa Makhija

Sabrina Peter

Jia Wei Siau

Shree Harsh Vijaya Chandra

Yin Nah Teo

Sydney Brenner

Phillipp Holliger

Leng Peng Walter Goh

Min Yen Lee

Walter Goh

Marc D'Abbadie

Marc d'Abbadie

Marc D'abbadie

The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.

Mutants of the bacteriophage lambda integrase

The present invention relates to methods and compositions for detecting an interaction between a protein and a ligand, comprising: (i) binding at least one fluorescent molecular rotor to said ligand or protein; and (ii) detecting a change in fluorescence emitted by said fluorescent molecular rotor after contact of the bound fluorescent molecular rotor with the other of said ligand or protein, thereby detecting an interaction between the ligand and the protein, wherein the fluorescent molecular rotor comprises: a rotating ?-bond; an electron-donating moiety; an electron-accepting moiety; and a ?-conjugated linker.

Fluorescent molecular rotors

The present invention is directed to p53 activating peptides. The present further describes methods for generating these peptides and the use of these peptides.

p53 activating peptides

The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described.

DNA polymerase

An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression system.

Emulsion compositions

Growing community of inventors

Singapore, Singapore

Farid Ghadessy