Mayo Foundation for Medical Education and Research

University of Illinois

Farhad Kosari

George Vasmatzis

Eric W Klee

John C Cheville

Lori S Tillmans

Rashid Bashir

Anurup Ganguli

George G Klee

Cemile D Savci-Heijink

Jan Marie A Willard

Marie-Christine Aubry

Cristiane M Ida

Cemile Dilara Savci Heijink

Jan-Marie Willard Munz

Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.

Spatial molecular analysis of tissue

This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome.

Predicting cancer outcome

This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.

Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation

This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein.

Extracellular and membrane-associated prostate cancer markers

Growing community of inventors

Rochester, MN, United States of America

Farhad Kosari