P B Diagnostic Systems, Inc.

Fareed Kureshy

Dina Frenkel

William J Lawrence

Ernest W Long

Shailendra Singh

Robert C MacIndoe, Jr

Gary Lee Webber

Charles A DeAngelis

Paul L Mullen

Assay module magazine holder

A temperature controlled chamber for an analytical instrument which includes a circular conveyor for transporting assay cartridges, the chamber enclosing the outer peripheral part of the conveyor on which the assay cartridges reside. The temperature controlled chamber has a bottom wall of polymeric material located beneath the conveyor, an outer wall of polymeric material extending upward above the conveyor, a metallic top wall and a metallic inner wall which extends downward to the upper surface of the conveyor. Thermal control, including rapid thermal response to compensate for temperature perturbations induced by periodic introduction of assay cartridges which are at a temperature less than that of the chamber, is accomplished by heating elements located above and below the conveyor. The heating elements are pulsed by an electrical circuit at a rate substantially faster than the rate of introduction of new assay cartridges. Pulses of electric current applied to the heating elements are modulated with pulse-width modulation to adjust the temperature within the chamber in response to signals emitted by a temperature sensor located within the chamber.

Temperature controlled chamber for diagnostic analyzer

An automated assay system includes a temperature controlled chamber with a conveyor therein. The conveyor carries berths past a port in a sidewall of the chamber to permit insertion and extraction of assay cartridges via the port into respective ones of the berths. An injector disposed outside the chamber and at the port includes a loader arm for advancing cartridges along a path through the port to accomplish insertion and extraction of a cartridge. A track is provided in the injector for guiding the assay module. A portion of the track connects by a swing arm to a pivot allowing the track portion to be swung away from the path for ejection of a cartridge. A door which provides for opening and closing of the port is connected to the swing arm to move concurrently with the swinging of the track portion. This allows for automatic closure of the port subsequent to an insertion or an extraction of a cartridge, and automatic opening of the port prior to insertion or extraction of the cartridge.

Incubator port closure for automated assay system

Diagnostic immunoassay machine

There is described an analytical isntrument for the analysis of fluids such as biological fluids. The instrument includes a fluid dispensing system having a pipette for dispensing fluid test samples and test reagents to assay cartridges. An optical detection system provides a light beam which intercepts a downward travel path of the pipette prior to its reaching the dispense position. Measurement of the intensity of the light beam in conjunction with the position of the pipette enables a controller to indicate the presence or absence of a pipette tip. In addition, interception of the light beam by the pipette initiates a final approach sequence for the pipette to the dispense position above an assay cartridge by a predetermined increment of travel.

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Westwood, MA, United States of America

Fareed Kureshy