Brown University

Research Corporation Technologies, Inc.

Fardos N Naguib

Mahmoud H El Kouni

Sungman Cha

Paul Calabresi

Shih H Chu

Ming Y Chu

Raymond Panzica

Vincent Guarcello

Pharmaceutical compositions comprising a pharmaceutical composition comprising a compound which is an .alpha. or .beta. anomer, a D(+) or L(-) enantiomer of the following structural formula: ##STR1## wherein, R.sub.1 is a halogen, OR.sub.6, SR.sub.6, SeR.sub.6 or CH.sub.2 R.sub.6 and R.sub.6 is alkyl, alkene, arylalkyl, or aryl; ##STR2## X is CH.sub.2, O or S; R.sub.3 is H, OH, or a halogen;

Treatment of toxoplasmosis

5-benzyl barbiturate compounds for use as water-soluble uridine phosphorylase inhibitors are disclosed. These compounds are useful for reducing the toxicity and anemia induced by antiviral drugs such as AZT, as well as for potentiating anticancer drugs and combatting their host-toxicity.

5-benzyl barbiturate derivatives

A compound of the Formula (I): ##STR1## where X is a benzyl group or a benzyloxybenzyl group and pharmaceutical preparations containing the same.

Hydroxymethyl derivatives of 5-benzylacyclouridine and

Growing community of inventors

Providence, RI, United States of America

Fardos N Naguib