Qingdao University of Science and Technology

Fanqing Meng

Xin Li

Jianguang Qi

Limei Zhong

Jianbo Jia

Zhaoyou Zhu

Yinglong Wang

Peizhe Cui

Lei Han

Wenhui Xu

Deping Du

Kaiguang Wang

Zhonghui Zheng

Zuxing Kou

Bingkun Xia

Shuli Yin

A process and a device for continuous flow side-chain alkylation which relate to the technical field of organic synthesis. In this process and the device for continuous flow side-chain alkylation, an ibuprofen raw material is prepared with alkylbenzene as a raw material. This raw material alkylbenzene is easily available and has a low cost, and is suitable for scale-up production. Moreover, an entire preparation process adopts continuous chemical synthesis, and a reaction time of each stage can be precisely controlled, which is beneficial to control a total reaction time and reduce an amount of impurities produced. In this way, a purity and a yield of the ibuprofen raw material are improved. In summary, a continuous synthesis method for side-chain alkylation of alkylbenzene provided by the present disclosure shows a low cost and a high yield.

Process and device for continuous flow side-chain alkylation

The present disclosure provides an active zinc-based catalyst and a preparation method thereof, and use in catalyzing a rearrangement reaction of ibuprofen. The active zinc-based catalyst includes a carbon-based fiber material and nano-zinc oxide supported on a fiber surface of the carbon-based fiber material. The active zinc-based catalyst is introduced with the carbon-based fiber material, and the carbon-based fiber material is capable of increasing a specific surface area of the catalyst, thereby improving a dispersion degree of zinc oxide, increasing the number of catalytic active sites, and significantly improving a catalytic activity. Meanwhile, due to a certain mechanical strength, the carbon-based fiber material is capable of improving a mechanical strength of the catalyst, making the catalyst exist stably in ketal fluid, maintaining a stable morphology of the catalyst, and avoiding or inhibiting reduction of the catalytic active sites, thereby ensuring a catalytic stability.

Active zinc-based catalyst and preparation method thereof, and use in catalyzing rearrangement reaction of ibuprofen

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Qingdao, China

Fanqing Meng