Centre National De La Recherche Scientifique

Université Paris-Sud 11

Fanny Schmidt

Bruno Figadere

Rita Raisman-Vozari

Pierre Champy

Xavier Franck

Laurent Ferrie

Gaël Le Douaron

Sylvia Rita Vozari

The present invention relates to compounds of formula (I) below: for which: &#x2014;X represents a hydrogen atom, a halogen atom, a group NOor NH, &#x2014;Rrepresents H or &#x2014;CH&#x2014;C&#x2261;CH, and &#x2014;Rand Reach represent, independently of one another, a hydrogen atom; a saturated or unsaturated, linear or branched hydrocarbon-based chain comprising from 1 to 10 carbon atoms; or an optionally substituted aryl group, and also the pharmaceutically acceptable salts thereof, the stereoisomers thereof or mixtures of stereoisomers thereof in any proportion, in particular for use thereof as a medicament, in particular in the treatment or prevention of neurodegenerative diseases, and also the processes for the preparation thereof and the pharmaceutical compositions comprising same. 

Aminoquinoxaline derivatives for treatment of neurodegenerative diseases

The invention relates to a compound of the following formula (I), 

Indole derivatives for treating neurodegenerative diseases

The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr&#x2014;X&#x2014;CHRR(I) in which: &#x2014;HetAr represents a group chosen from: &#x2014;X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an &#x2014;NH&#x2014; or &#x2014;NH&#x2014;CO&#x2014; group, &#x2014;Rrepresents a hydrogen atom or an &#x2014;OH, &#x2014;O(C-C)alkyl, &#x2014;OCO((C-C)alkyl), &#x2014;OSO((C-C)alkyl) or &#x2014;OSOH group, and &#x2014;Rrepresents a hydrogen atom or a (C-C)alkynyl, (C-C)alkenyl or (C-C)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases. 

Quinoline or quinoxaline derivatives for treating neurodegenerative diseases

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Chatenay Malabry, France

Fanny Schmidt