Syngenta Crop Protection, Inc.

Syngenta Corporation

Sungenta Limited

Syngenta Participations Ag

Gottfried Seifert

Hans Tobler

Martin Zeller

Ian Kevin Jones

Neil George

Harald Walter

Paul Edward Bonnett

Josef Ehrenfreund

Shailesh C. Shah

Camilla Corsi

Fanny Giordano

Denis Gribkov

Shailesh Shah

Alain De Mesmaeker

Bjorn Antelmann

Juerg Wiss

Martin Charles Bowden

Beat Jau

Linhua Wang

Thomas Vettiger

Dominik Faber

Paul Bonnett

Adrian Müller

Martin Lager

Thomas Aitcheson Clark

Hans-Dieter Schneider

The present invention relates to a novel process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises    

Process for the preparation of benzonorbornenes

The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCI, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCI, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst. 

The present invention relates to a process for the preparation of compounds of formula I wherein Rand Rare each independently of the other hydrogen or C-Calkyl and Ris CFor CFH, by wherein Rand Rare as defined for formula I, with at least one reducing agent to form a compound of formula III wherein Rand Rare as defined for formula I, and wherein Rand Rare as defined for formula I, and wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C-Calkoxy and Ris as defined for formula I, to form the compound of formula I;and to novel intermediates for use in that process.

Process for the production of amides

The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide. 

Process for the preparation of pyrazole carboxylic acid amides

A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).

Process for the synthesis of mandipropamid and derivatives thereof

A process for the production of a compound of formula (I), which comprises a) reacting a compound of formula (II), wherein Rand Rare both independently C-Calkyl, with methylhydrazine in the presence of water and a water-immiscible organic solvent being inert in saponification reactions, to form a compound of formula (III) wherein Ris as defined for formula (II) and b) saponifying that compound in situ leading to the formation of the compound of formula (I) by b1) adding a base to form the anion of the compound of formula (I) and then adding an; acid to form the compound of formula (I); or b2) adding an acid to form the compound of formula (I). 

Process for the production of pyrazoles

The present invention relates to a process for the preparation of compounds of formula (I) wherein Rand Rare each independently of the other hydrogen or C-Calkyl and Ris CFor CFH, by a) reaction of a compound of formula (II) wherein Rand Rare as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein Rand Rare as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein Rand Rare as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C-Calkoxy and Ris as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process. 

The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein Rand Rare independently H or Calkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein Rand Rhave the meanings given for the compound of the formula (I), Ris H or Calkyl and Ph is phenyl, or a compound of the general formula (III), wherein R, R, Rand Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R)&#x2014; from the benzylamino moiety PhCH(R)NH&#x2014; in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2,3-double bond and the double bond joining the RRC&#x2014; moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides. 

Process for the preparation of amines

Growing community of inventors

Muenchwilen, Switzerland

Fanny Giordano