Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Fangfang Jin

Qing Dong

Piaoyang Sun

Qiyue Hu

Feng He

Wei He

Bin Wang

Fei Li

Weikang Tao

Jiong Lan

Guoqing Cao

Jianbiao Peng

Biao Lu

Bonian Liu

Xiaotao Li

Chunzhou Han

Chunyan Gu

Xianbo Liu

Junzhen Zhang

A 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine are provided. Specifically, a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, in particular as an Aor Areceptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the Aor Areceptor are provided. Each substituent in general formula (I) is defined in the description. 

1,2,4-triazine-3-amine derivative, preparation method therefor, and use thereof in medicine

Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description. 

Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof

Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification. 

Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof

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Shanghai, China

Fangfang Jin