Sunshine Lake Pharma Co., Ltd.

North & South Brother Pharmacy Investment Company Limited

Fangfang Huang

Xin Huang

Jinsong You

Shuiwang Feng

Yuzhen Xu

Feng Zhao

Zhiyong Li

Zhengshang Zhou

Lianying Zhu

Xinqian He

Weiqiang Hong

Yong Jiang

Beiyang Yao

Ni Wang

Ning Tian

Qibiao Huang

Dailong Fang

Xiaomiao Qiu

A lurasidone solid dispersion and a preparation method thereof. The solid dispersion includes a mixture of lurasidone, a pharmaceutical carrier and a plasticizer, in which the lurasidone is in a free base form. The lurasidone solid dispersion obtained by the preparation method has characteristics of high dissolution rate (over 30%) in partial neutral medium (such as pH 6.0), significantly increased bioavailability, and significantly reduced food effect, which overcomes the excessive medication limitation in the prior art, avoids the reduction or even inefficiency of the curative effect caused by improper medication of patients, ensures the normal exertion of the medication effect, thereby increases the flexibility and compliance of patients to take medicine.

Lurasidone solid dispersion and preparation method thereof

Disclosed herein are inclusion complexes comprising vilazodone or a pharmaceutically acceptable salt thereof and an inclusion material, compositions and pharmaceutical formulations comprising the inclusion complexes, and methods for preparing the inclusion complexes, compositions or pharmaceutical formulations.

Vilazodone inclusion complexes, compositions and preparation thereof

Disclosed is a type of borosilicate glass, the composition of which, based on oxides, contains the following components by weight percentage (wt %): 2.0 wt %-5.0 wt % of TiO, 0.25 wt %-2.5 wt % of CeOand 0.25 wt %-3.0 wt % of YO, and does not contain any iron compound, such as ferric oxide. The glass has better UV resistance and alkaline resistance properties, and a better light transmission rate, and is particularly suitable for use in the field of pharmaceutical packaging materials.

UV-resistant and alkaline-resistant borosilicate glass and use thereof

It relates to a lurasidone solid dispersion and a preparation method, wherein the method comprises melting treatment of a mixture containing lurasidone, a medicinal hot melt carrier, optionally an acidic regulator and plasticizer in order to obtain the solid dispersion described herein, and wherein the lurasidone is provided in a form of free base. The lurasidone solid dispersion obtained by the preparation method according to the example of the invention has the characteristics of high dissolution rate (dissolution rate can reach 30%-70%) in a partial neutral medium (e.g. pH6.0). The bioavailability of lurasidone solid dispersion increased significantly and the food effect of lurasidone solid dispersion prepared from the example decreased remarkably. It overcomes the limitation of too many medication in the prior art and avoids the reduction of curative effect of the improper medication for the patient or even invalid, ensures the normal efficacy, thereby increases the patient's medication flexibility and compliance.

The present invention provided an apixaban solid composition and a preparation method thereof. The method comprises granulating apixaban by wet granulation, wherein the apixaban has a particle size Dmore than 89 &#x3bc;m.

Apixaban solid composition and preparation method thereof

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Dongguan, China

Fangfang Huang