Agency for Science, Technology and Research

Other

Fang Xie

Zhiqiang Gao

Hong Xie

Jackie Yi-Ru Ying

Guolin Xu

Mohamed Shariff Mohamed Arshad

The invention is directed to a compound having the general formula (1): 

DNA threading intercalators

A threading intercalator of general formula I:IG-DG-IG-(DG-IG)&#x2003;&#x2003;(I)wherein IG, IG, and IGare the same or different and represent an intercalating group comprising a planar polyaromatic group; wherein DG represents an electrochemical, a chemiluminescent, a catalytic or an electrochemiluminescent detectable group; and wherein n represents 0 or 1. This invention also relates to a process of detecting a double strand nucleic acid molecule using the threading intercalator.

Detectable threading intercalator

An electrically non-conductive, nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIIB or VIIIB of the Periodic Table, and wherein an oxidoreductase enzyme and a polymeric redox mediator capable of transferring electrons are diffusibly dispersed in said nanoparticulate membrane.

Electrically non-conductive, nanoparticulate membrane

The invention is directed to a compound having the general formula (I): wherein

Compositions and methods for electrochemical detection of nucleic acid are disclosed. The compositions comprise electrocatalytic intercalators that bind to double-stranded nucleic acid and oxidize nucleic acid. Methods of detecting nucleic acid in a sample comprise forming double-stranded nucleic acid that is bound by electrocatalytic intercalators wherein the intercalators catalyze oxidation of the nucleic acid at the surface of an electrode.

Determination of nucleic acid using electrocatalytic intercalators

Disclosed herein are novel high oxidation state metallocene compounds, processes for preparing these compounds and uses of these compounds.

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Sydney, Australia

Fang Xie