Massachusetts Institute of Technology

Fang Wang

Omer Yilmaz

Stephen J Lippard

George Eng

Jonathan Braverman

The present invention provides compositions comprising &#x3b2;-hydroxybutyrate, cyclic or linear &#x3b2;-hydroxybutyrate oligomers, and/or &#x3b2;-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject.

Beta-hydroxybutyrate encapsulated PLGA nanoparticle compositions

Platinum-containing compounds are generally described. For example, compounds of Formula (II) are generally described. Inventive compositions and uses thereof are also described. For example, methods of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a compound of Formula (II) are generally described. 

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Cambridge, MA, United States of America

Fang Wang