Syntex (u.s.a.) Inc.

Fang-Ting Chiu

Robin D Clark

Joseph M Muchowski

Jacob Berger

John O Gardner

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently --H or lower alkoxy;

Method for treating cardiovascular disease with calcium channel

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 and each independently --H or lower alkoxy; R.sub.3 and R.sub.4 are each independently lower alkyl; and R.sub.5 and R.sub.6 are each --OCH.sub.3, or together form --OCH.sub.2 O-- or --OCH.sub.2 CH.sub.2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.

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Union City, CA, United States of America

Fang-Ting Chiu