Kaohsiung Medical University

Other

Duke University

University of North Carolina at Chapel Hill

Metal Industries Research & Development Centre

Chang Gung University

China Medical University

We-win Applied Bio-tech Co., Ltd.

We-win Bio-medical Co., Ltd.

Fang-Rong Chang

Yang-Chang Wu

Chin-Chung Wu

Ying-Chi Du

An-Shen Lin

Tung-Ying Wu

Yi-Hong Tsai

Mei-Chin Lu

Hui-Chun Wang

Tusty-Jiuan Hsieh

Lien-Chai Chiang

Tsong-Long Hwang

Kuo-Hsiung Lee

Hui-Ping Hsieh

Bing-Hung Chen

Chen Hsieh

Chun-Yu Chen

Mu-Yi Hua

Suh-Hang Hank Juo

Shih-Wei Wang

Tzu-Chen Kuo

Hung-Wei Yang

Chin Ho Chen

Pei-Jung Lien

Chuan-Chia Sun

Yu-Ming Hsu

Juan-Cheng Yang

Sheng-Chung Yang

Chih-Hsin Wang

Da-Wei Chuang

Hsue-Yin Hsu

Yojiro Sakurai

Kartiko Arif Purnomo

Yen-chang Chen

Chia-Hua Liang

Yung-Fong Tsai

Liang-Mou Kuo

Yuan-Bin Cheng

Shih-Tung Liu

Mei-Hui Lin

Chi-Ting Hsieh

Yang-chang Wu

A use of extracts of roselle seeds for preparing a composition of antioxidant, anti-inflammation, anti-UVB, anti-allergy, whitening, moisturizing, and anti-wrinkle, wherein the extracts of the roselle seeds comprise lauric, palmitic, linoleic, oleic, or stearic acids; and a method for preparing the extracts of the roselle seeds comprises steps of: steeping of: extracting a weight ratio of the 12:1 to 20:1 roselle seeds and an ethanol solution with a concentration of 75 to 95%; and steeping the roselle seeds in the ethanol solution to obtain a suspension; and extraction of: the suspension being engaged in an extraction of a continuous and rapid oscillation with an ultrasonic energy with a total energy of 200 to 500W, wherein 1 to 3 hours of the oscillation is one cycle, and a total number of 3 to 5 cycles is lasted, in order to obtain roselle seed crude extracts.

Antioxidant, anti-inflammatory, ANTI-UVB, anti-allergic, whitening, and anti-wrinkle roselle seed extract

The present invention relates to a maca extract and uses thereof. The part of the maca extract extracted with polar solvent has anti-thrombotic activity, the part of the maca extract extracted with medium and low polarity solvents has anti-neutrophilic inflammatory and anti-allergic activities, the part of the maca extract extracted with low polarity solvent has anti-neutrophilic inflammatory activity and has pro-angiogenic activity.

Maca extract and use thereof

This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition has the capacity to treating or preventing a virus infection in a subject. 

Methods and compositions for inhibition of ATR and FANCD2 activation

Theextract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain theextract. This supercriticalextract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, theextract further is able to be prepared as food supplement and pharmaceuticals.

Extract offrom supercritical fluid extraction for treating diabetes and metabolic disease, the preparation method and the use thereof

The present invention relates to phorbol esters from the seeds ofby a series of chromatographic processes, and compositions containing these congeners for the treatment of allergic responses.

Compositions and methods of antiallergic phorbol ester and phorbol derivatives as the main active ingredients from the seeds of aquilaria malaccensis

This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject. 

Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4'-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR&#x3b3; inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR&#x3b3; ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1&#x3b2; (IL-1&#x3b2;) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).

Composition for treating atherosclerosis and a preparation method thereof

Disclosed herein are novel formyl peptide receptor 1 (FPR1) antagonists and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders mediated by FPR1.

Formyl peptide receptor 1 antagonists and uses thereof

Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.

Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids

A preparation method for a water extract of the fruiting body of(ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract frominduces the maturation of dendritic cells, enhances T cell proliferation and INF-&#x3b3; production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.

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Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.

Inhibition of biofilm formation by 1,2,3,4,6-penta-O-galloyl-D-glucopyranose

Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.

Composition for treating diabetes and metabolic diseases and a preparation method thereof

New pharmaceutical compositions extracted from-are confirmed to effectively treat influenza A (HN) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting-with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.

A compound for inhibiting activity of glutathione s-transferase omega 1 is provided and is represented by the following Formula 1:  

Use of compound for inhibiting glutathione s-transferase omega 1 activity and method for synthesizing the same

Growing community of inventors

Kaohsiung, Taiwan

Fang-Rong Chang