Tianma Micro-electronics Co., Ltd.

General Electric Company

Finisar Corporation

Other

Koninklijke Philips Corporation N.V.

Via Technologies, Inc.

Shanghai United Imaging Healthcare Co., Ltd.

Micro Focus Lcc

Nxp B.v.

Carrier Corporation

Merck Sharp + Dohme Corp.

Lear Corporation

Volvo Car Corporation

Ii-vi Delaware, Inc.

Basf Se Corporation

Fang Liu

Shuhui Chen

Lingyun Wu

Jian Li

Jeremy Mark Travins

Tao Guo

Zhaoguo Chen

Francesco Gerald Salituro

Peng Zhang

Jeffrey O Saunders

Janeta Popovici-Muller

Kevin X Chen

Shunqi Yan

Giovanni Cianchetta

Huiping Li

Xiaoxu Hu

Ting Yan

Xiao Liu

Xiaojun Wu

Byron Delabarre

Chaofeng Long

Xiaoxin Chen

Zhuowei Liu

Cheng Xie

Anthony Donofrio

Markus Schuette

Yanxin Yu

Kai Zhou

Caibin Xiao

Yutian Wei

Huade Shu

Leo Yu-yu Lin

Xinde Chen

Li Sun

Zheng Wang

Guoping Hu

Bing Zhang

Yangang Liang

Xiangming Hou

Yihong Yao

Jiaqi Huang

Lele Zhao

Ping F Chen

Chao Zhi

Wen-Chung Chen

Xi Xi Liu

Xun Ye

Boyu Hu

Xiaofei Wang

Bingzhi Chen

Xing Liu

Chao Chen

Wei Zhu

Fei Wang

Wei He

Peng Wang

Michael D Altman

Alan B Northrup

Daniel Guay

Michelle R Machacek

Yves Ducharme

Solomon D Kattar

Wei Cai

Fan Chen

Ryan D Otte

Andrew M Haidle

Michael Hale Reutershan

Su Lu

John Michael Ellis

Matthew Christopher

Jonathan B Grimm

Jianqi Li

Qingxia Wang

Jun Zhu

Xin Yao

Fuchun Zhan

Yanfeng Li

Kaleen Konrad Childers

Kerrie Spencer

Jian Qing

Christian Beaulieu

Lin Zhu

Brandon D Cash

Linhui Chen

Shigui Zhu

Eric Thomas Romeo

Ernest Kin Man To

Yun Lu

Yuanshan Yao

Lijuan Chen

Tinghua Yun

Brendan O'Boyle

Jiaping He

Dilrukshi Vitharana

Xiawei Wei

Zhixin Zheng

The present disclosure discloses a class of macrocyclic derivatives, and specifically discloses a compound shown in formula (VI), a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.

Macrocyclic derivative and use thereof

The present invention provides a reagent and method for detecting a replication-competent lentivirus (RCL) by fluorescence quantitative real-time polymerase chain reaction (PCR). In particular, the present invention provides a primer and probe combination for detecting RCL, and a method for performing detection using said primer and probe; the present invention also provides a reagent kit comprising said primer and probe. The primer and probe combination of the present invention detects RCL with high amplification efficiency and good specificity, and can be used for RCL detection and RCL monitoring of clinical patient peripheral blood samples which may occur during a production process.

Reagent and method for fluorescence quantitative real-time PCR detection of RCL

A vehicle operating apparatus including a stressed means configured to receive a force applied thereon by a driver for operating a vehicle; a connecting means configured such that a first end is mechanically connected to the stressed means and a second end is mechanically connected to a mounting surface of the vehicle; a sensor configured to sense information associated with the force applied by the driver and convert the information into an electrical signal, the vehicle is able to perform driving-related operations in response to the signal; and an actuating means configured to actuate the connecting means according to a current driving state of the vehicle so that the stressed means is maintained at a specific position.

Vehicle operating apparatus, vehicle system and vehicle braking system

Provided is a method for large-scale production of lentivirus by using GMP-level serum-free suspension cells. Said method comprises the following steps: (a) providing a seed solution of packaged cells; (b) inoculating the seed solution in a first culture solution; (c) carrying out subculture of the packaged cells; (d) starting a liquid change operation when a liquid change trigger condition is met; (e) repeating steps (c) and (d) 1, 2 or 3 times; (f) starting a transfection operation when a transfection trigger condition is met; (g) optionally performing liquid change after transfection; (h) cultivating the transfected packaged cells; (i) starting harvesting and liquid change operations when a liquid change trigger condition is met; (j) repeating steps (h) and (i) 1, 2 or 3 times; (k) combining each of the recovered liquids; and (l) performing a purifying treatment. The culture solution used in each step is a serum-free cell culture solution.

Method for large-scale production of lentivirus by using GMP-level serum-free suspension cells

The present invention relates to a group of pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof

Provided is a method for large-scale preparation of a purified preparation of a recombinant lentiviral vector at the GMP grade. The method comprises: (a) providing raw material feed liquid to be purified that comprises recombinant viral vectors; (b) carrying out a microfiltration treatment on the feed liquid to obtain a microfiltered filtrate comprising the recombinant viral vectors; (c) optionally concentrating the filtrate to obtain a concentrated filtrate; (d) purifying the filtrate obtained in the previous step by means of chromatography to obtain a crude pure product comprising the recombinant viral vectors; and (e) subjecting the crude pure product obtained in the previous step to liquid exchange and elaborate purification to obtain the purified recombinant viral vectors.

Method for large-scale preparation of purified preparation of recombinant lentiviral vector at GMP grade

Provided is a method for large-scale production of lentivirus by using GMP-level serum-free suspension cells. Said method comprises the following steps: (a) providing a seed solution of packaged cells; (b) inoculating the seed solution in a first culture solution; (c) carrying out subculture of the packaged cells; (d) starting a liquid change operation when a liquid change trigger condition is met; (e) repeating steps (c) and (d) 1, 2 or 3 times; (f) starting a transfection operation when a transfection trigger condition is met; (g) optionally performing liquid change after transfection; (h) cultivating the transfected packaged cells; (i) starting harvesting and liquid change operations when a liquid change trigger condition is met; (j) repeating steps (h) and (i) 1, 2 or 3 times; (k) combining each of the recovered liquids; and (1) performing a purifying treatment. The culture solution used in each step is a serum-free cell culture solution.

A squeeze-enhanced axial transformer (SeaFormer) for mobile semantic segmentation is disclosed, including a shared stem, a context branch, a spatial branch, a fusion module and a light segmentation head, wherein the shared stem produces a feature map; the context branch obtains context-rich information; the spatial branch obtains spatial information; the fusion module incorporates the features in the context branch into the spatial branch; and the light segmentation head receives the feature from the fusion module and output the results. This application is also related to the layer of the SeaFormer, as well as methods thereof.

Squeeze-enhanced axial transformer, its layer and methods thereof

A method for accelerating score-based generative models (SGM) is provided, including setting a frequency mask (R) and a space mask (A) and a target sampling iteration number (T); sampling an initial sample (x); conducting iteration comprising steps as follows: sampling a noise term; applying a preconditioned diffusion sampling (PDS) operator (M) to the noise term and thus generate a preconditioned noise term; calculating a drift term; applying the transpose of the PDS operator (M) and then applying the PDS operator (M) to the drift term, and thus generate a preconditioned drift term; diffusing the sample of each iteration (x); and outputting the result.

Method and system for accelerating score-based generative models with preconditioned diffusion sampling

Disclosed in the present invention are a crystal form of a [1,2,4]triazolo[1,5-c]pyrimidine compound and a preparation method thereof. Further disclosed is a use of the crystal form in the preparation of a medicament for treating Areceptor related diseases. 

Crystal form a of (5-amino-8-(2-methyl-6-(trifluoromethyl)pyridin-4-yl)-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methanol (compound 1)

An armrest release mechanism includes a pivot bush. A release bracket is fixed to the pivot bush. An armrest pivot is supported on the pivot bush for relative rotational movement. A release board is also supported on the pivot bush for relative rotational movement. The release board is movable between a locked position and an unlocked position. An armrest lock is attached to the release bracket for relative movement. The armrest lock is also attached to the release board. When the release board is in the locked position the armrest lock is engaged with the armrest pivot to prevent movement of the armrest pivot relative to the pivot bush. When the release board is in the unlocked position the armrest lock is not engaged with the armrest pivot.

Vehicle armrest with automatic retraction

A method may include thinning a silicon wafer to a particular thickness. The particular thickness may be based on a passband frequency spectrum of an adjustable optical filter. The method may also include covering a surface of the silicon wafer with an optical coating. The optical coating may filter an optical signal and may be based on the passband frequency spectrum. The method may additionally include depositing a plurality of thermal tuning components on the coated silicon wafer. The plurality of thermal tuning components may adjust a passband frequency range of the adjustable optical filter by adjusting a temperature of the coated silicon wafer. The passband frequency range may be within the passband frequency spectrum. The method may include dividing the coated silicon wafer into a plurality of silicon wafer dies. Each silicon wafer die may include multiple thermal tuning components and may be the adjustable optical filter.

Optical adjustable filter sub-assembly

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Therapeutically active compounds and their methods of use

In one example, a system for gesture buttons can include a processing resource and a non-transitory computer readable medium having stored thereon instructions to cause the processing resource to perform a first function in response to a gesture provided to the user interface, display a gesture button on the user interface, and perform a second function that is different than the first function in response to the gesture provided on the gesture button displayed on the user interface.

Gesture buttons

Growing community of inventors

Shanghai, China

Fang Liu