Bayer Healthcare LLC

Bayer Schering Pharma Ag

Psioxus Therapeutics Limited

Fang Jin

Terry Hermiston

Peter Kretschmer

Maxine Bauzon

Richard N Harkins

The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method.

Methods and compositions for production of recombinant protein in HBX-expressing mammalian cells

The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.

Generation of replication competent viruses for therapeutic use

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Danville, CA, United States of America

Fang Jin