Leland Stanford Junior University

Fan Yang

Xinming Tong

Li-Hsin Han

Stuart Barry Goodman

Eva Carolina González Díaz

Michael Gerard Keeney

Engineered tissue models based on three-dimensional (3D) scaffolds, also referred to herein as tissue-engineered 3D models, can be used as in vitro diagnostic and drug screening tools for predicting, preventing and/or treating cancer metastases.

Tissue engineered 3D models for cancer metastasis

Macroporous 3-D tissue engineering scaffold comprising elastomeric cross-linked polymer units and interconnected macropores containing living cells are produced by step of: in a mixture of the cells and elastomeric polymer units comprising activatable crosslinking groups, activating the crosslinking groups to form the scaffold.

Macroporous 3-D scaffolds for tissue engineering

A bone implant primer is provided. A biodegradable hydrogel component is provided. A plurality of biomolecule release depots are dispersed within the biodegradable hydrogel component wherein the plurality of biomolecule release depots comprise biomolecules for aiding implant osseointegration or biomolecules for mitigation of foreign body response. Different biomolecules may be released by the microspheres at different times.

Injectable hydrogel system to modulate host response at bone implant interface

Macroporous 3-D tissue engineering scaffold are manufactured by contacting an article comprising multiple distinct macroparticulate porogens distributed within a polymer scaffold, wherein the porogens are selectively and sequentially dissolvable by corresponding biocompatible stimuli.

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Palo Alto, CA, United States of America

Fan Yang