Denovamed Inc.

Other

University Health Network

Treventis Corporation

Denouamed, Inc.

Fan Wu

Christopher J Barden

Erhu Lu

Donald F Weaver

Christopher McMaster

Thomas Kuchurean Wood

Mark A Reed

Arun Yadav

Shengguo Sun

Scott C Banfield

Michael G Brant

Jake Goodwin-Tindall

Stephanie Wohnig

Autumn Meek

Paolo Schiavini

Chris Barden

David Byers

Christopher R McMaster

Annette Henneberry

Fuqiang Ban

Donald Weaver

A compound 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole, methods for the manufacture of said compound, topical compositions comprising said compound and methods of use thereof in the topical treatment of infections caused by pathogenic bacteria at a wound site.

5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole for the topical treatment of bacterial infections

Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided. 

Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof

Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant: 

Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial

In general, among other things, compounds of Formula I are provided: in which Ris e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N,N,N-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; Ris, e.g., phenyl optionally substituted with one or more substituents; and Rand Rare each independently hydrogen or alkyl. Methods of treatment are also provided.

Anti-amyloid compounds containing benzofurazan

Among other things, in general, antimicrobial and/or adjuvant compounds are provided according to Formula Ia: (Ia) in which E and R1-11 have the meanings described herein; and prodrugs and pharmaceutically acceptable salts thereof. Other formulae and methods of use are also provided. 

Antimicrobial/adjuvant compounds and methods

The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

Synthesis of novel antimicrobials

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Toronto, Canada

Fan Wu