Vanderbilt University

Southern Illinois University

Duke University

Fan Shi

Boyd M Goodson

Eduard Y Chekmenev

Aaron M Coffey

Roman V Shchepin

Milton L Truong

Warren S Warren

Thomas Theis

Quinn A Best

Bryce E Kidd

Yuqing Hou

Kirsten A Groome

Miranda Limbach

Jamil A Mashni

Ping He

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

Cleavable agents

Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.

Method for creating hyperpolarization at microTesla magnetic fields

Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Water soluble catalysts for NMR/MRI enhancement

Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

Heterogeneous catalysts for NMR/MRI enhancement via signal amplification by reversible exchange (SABRE)

Growing community of inventors

Energy, IL, United States of America

Fan Shi