Zhejiang University

Fan Jiang

Ruiliang Bai

The present invention discloses a diffusion magnetic resonance (MR) method for measuring arterial pulsation dependence of perivascular cerebrospinal fluid flow in glymphatic system: DTI acquisition: Brain MRI images were acquired using dynamic diffusion tensor imaging (DTI); Cardiac signal synchronization: Simultaneously collect heart rate fluctuation time-series signals; Peak coordinate determination: Identify the peak timing of cardiac pulsation signals from the time-series data; Image realignment: Reorganize brain MR images according to their temporal positions within the cardiac cycle; Temporal interpolation: Perform uniform time-sampling reconstruction to generate equidistant diffusion MRI datasets across the cardiac cycle; Parameter calculation: Compute axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) at each voxel level; Mask-based analysis: Generate characteristic curves of AD/RD/MD and spin density(S) dynamics using region-specific masks in individual space. This method enables non-invasive measurement of: (1) Cerebrospinal fluid (CSF) flow velocity/direction in large perivascular spaces during heartbeats; (2) Microvascular perivascular CSF dynamics through diffusion parameter analysis.

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Hangzhou, China

Fan Jiang