Baxter Aktiengesellschaft

Baxalta Gmbh

Immuno Aktiengesellschaft

Falko-Gunter Falkner

Friedrich Dorner

Michael Pfleiderer

Georg Holzer

Johann J Eibl

Friedrich Scheiflinger

Bernhard Fischer

Artur Mitterer

Hanspeter Rottensteiner

Uwe Schlokat

Franziska Horling

Johannes Lengler

Codon-altered polynucleotides encoding Factor IX variants for expression in mammalian cells are provided, including sequences with high nucleotide sequence identity to the CS02, CS03, CS04, CS05, and CS06 sequences. Mammalian gene therapy vectors, such as adeno-associated viral vectors, and methods for treating hemophilia B using those vectors are also provided.

Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia B

Prothrombin derivatives

The present invention relates to methods of producing recombinant molecules including the nucleotide sequence for the structure of the preS1 region of the surface glycoprotein of the hepatitis B virus, and to compositions of the molecules. Compositions of the recombinant molecules may include a promoter and a marker gene. Cloning vectors are used to incorporate the recombinant molecules into hosts. Cells infected with the chimeric vaccinia produce high levels of preS1 protein. Isolation and purification of the preS1-containing protein is facilitated by the use of a recombinant molecule in which the myristylation site has been deleted by a modification of the nucleotide sequence. The purified preS1-containing protein is useful for development of vaccines, diagnostic kits and therapies.

High level expression of polypeptide that contains modified preS1 region

Defective poxviruses that lack a function imparted by an essential region of its parental poxvirus are provided for protein production and vaccination. A DNA polynucleotide encoding a protein is inserted into the defective poxvirus and placed under transcriptional control of a promoter. The defective poxvirus is viable when the lost function of the essential region is complemented by a host cell, transgenic animal or helper virus.

Recombinant poxviruses with foreign DNA in essential regions

recombinant poxviruses with foreign DNA in essential regions

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Mannsdorf, Austria

Falko-Gunter Falkner