Beutsches Rheuma-forschungszentrum Berlin (drfz)

Imtec Immundiagnostika Gmbh

Falk Hiepe

Andreas Radbruch

Gerd-Rudiger Burmester

Hyun-Dong Chang

Gabriele Riemekasten

Bimba F Hoyer

Jeannette Marell

Velia Gerl

Adriano Taddeo

Andreas Theiel

The invention relates to a composition comprising an anchor region capable of binding to a plasma cell; and a binding region associated with the anchor region, wherein the binding region binds a specific plasma cell antibody.

Compositions and methods

Peptides of the antigen Sm-D and their use, in particular for the diagnostics of the SLE. The invention relates to peptides of the antigen Sm-D, comprised of 35 to 45 amino acids, which form a conformation epitope and which are capable of binding autoantibodies, such as they occur in connection with systemic lupus erythematosus (SLE). Particularly preferred is the peptide of 37 amino acids with the structure VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR (SEQ ID NO:3) and its mutants and variants, respectively.

Peptides of the antigen Sm-D and their use, in particular for the

Growing community of inventors

Berlin, Germany

Falk Hiepe