Koninklijke Philips Corporation N.v.

Falco Cornelius Marinus Jacobus Maria Van Delft

Pieter Jan Van Der Zaag

Roelof Koole

Emiel Peeters

Reinder Coehoorn

The invention relates to an apparatus () and a method for the processing of single molecules, particularly for the sensing or sequencing of single-stranded DNA. A bottom layer () and an electrically conductive top layer () with a first and a second slit (), respectively, are disposed on top of each other such that an aperture (A) is formed by the slits. The slits () are preferably perpendicular to each other. An electrical circuit () may be connected to the top layer (), allowing to sense single molecules that pass through the aperture (A).

Apparatus for the processing of single molecules

The invention relates to a method for manufacturing an apparatus for the processing of single molecules. According to this method, a self-assembling resist () is deposited on a processing layer (, PL) and allowed to self-assemble into a pattern of two phases (). One of these phases () is then selectively removed, and at least one aperture is generated in the processing layer (, PL) through the mask of the remaining resist (). Thus apertures of small size can readily be produced that allow for the processing of single molecules (M), for example in DNA sequencing.

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Eindhoven, Netherlands

Falco Cornelius Marinus Jacobus Maria Van Delft