Sandoz Gmbh

Sandoz Pharm. Corp.

Sandoz Pharmaceuticals Corp.

Faizulla G Kathawala

John G Heider

Goetz E Hardtmann

Sompong Wattanasin

Eugene E Galantay

Paul L Anderson

Sandor Barcza

Nicholas A Paolella

Compounds of the formula ##STR1## wherein one of R and R.sub.o is ##STR2## and the other is primary or secondary C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-6 cycloalkyl or phenyl-(CH.sub.2).sub.m --, wherein

Indole analogs of mevalonolactone and derivatives thereof

Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

Idene analogs of mevalonolactone and derivatives thereof

Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom;

Azaindole derivatives useful as cholesterol biosynthesis inhibitors

Compounds of the formula ##STR1## and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis.

Pyrazolopyridine analogs of mevalonolactone and derivatives thereof

Compounds of the formula ##STR1## wherein one of R and R.sub.o is ##STR2## and the other is primary or secondary C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-6 cycloalkyl or phenyl(CH.sub.2).sub.m --, wherein

Intermediates in the synthesis of indole analogs of mevalonolactone and

The compounds are secondary amides of the formula

Amides of 2-alkynoic acids and use for inhibiting accumulation of

Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. .alpha.-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate tryptophan ester.

N-Unsaturated fatty acid amides of tryptophan ester homologues and

Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;

Para-amino benzoic and phenylacetic acid derivatives

Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate amino compound.

Cyclopropanyl-bearing amides of tryptophane

The compounds are free hydantoin derivatives of the formula: ##STR1## wherein X is a divalent radical consisting of from 2 to 5 linked units; one unit being --O--, and from one to 4 hydrocarbon units, independently, having the structure

Inhibiting growth hormone secretion with 5,5-substituted hydantoin

Carbalkoxy-phenyl (or tolyl)-dialkyl-or alkyl-phenyl-sulfonium salts, e.g. p-(.alpha.-carbethoxy) tolyl-n-octadecyl-phenyl sulfonium tetrafluoroborate, are useful as pharmaceuticals. The compounds are obtainable by reaction of a carbalkoxy-phenyl (or-tolyl)-dialkyl-or-alkyl-phenyl-sulfide with an alkylhalide in the presence of a metal salt, e.g. silver tetrafluoroborate.

Carboxyl-(phenyl or tolyl)-sulfonium salts

Alkyl diaryl sulfonium salts, e.g., cyclopropyl diphenylsulfonium tetrafluoroborate, are useful as hypoglycemic agents.

Alkyl diaryl sulfonium salts

Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides

Higher alkyl diaryl sulfonium salts, e.g., octadecyldiphenylsulfonium tetrafluoroborate, are useful as anti-obesity agents.

Higher alkyl diaryl sulfonium salts

Cyclopropyl alkyl arylsulfonium salts, e.g., cyclopropyl n-propyl phenylsulfonium tetrafluoroborate, are useful as pharmaceutical agents.

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West Orange, NJ, United States of America

Faizulla G Kathawala