Quantum-Si Incorporated

Other

Faisal R Ahmad

Jonathan Marc Rothberg

Paul E Glenn

Jonathan C Schultz

Todd Rearick

Lawrence Camest West

Jason W Sickler

Jose Camara

Jeremy Christopher Jordan

Keith Glen Fife

Jack L Jewell

Benjamin Cipriany

Farshid Ghasemi

John Glenn

Brittany Lathrop

Brendan Huang

Todd Roswech

Brett J Gyarfas

Michael Ferrigno

Jonathan M Rothberg

Xinghua Shi

Alexander Goryaynov

Joseph D Clark

Mel Davey

Tom Thurston

Craig Wenger

Daniel B Frier

Thomas Connolly

Andrey V Okishev

Michael Bellos

Systems and methods are described for producing an amplitude-modulated laser pulse train. The laser pulse train can be used to cause fluorescence in materials at which the pulse trains are directed. The parameters of the laser pulse train are selected to increase fluorescence relative to a constant-amplitude laser pulse train. The amplitude-modulated laser pulse trains produced using the teachings of this invention can be used to enable detection of specific molecules in applications such as gene or protein sequencing.

Amplitude-modulated laser

A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.

Hand-held, massively-parallel, bio-optoelectronic instrument

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.

Compact mode-locked laser module

Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.

Data acquisition control for advanced analytic instruments having pulsed optical sources

Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.

Optical sources for fluorescent lifetime analysis

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

Pulsed laser and bioanalytic system

A method and apparatus for characterizing an optical element. The optical element is part of a laser and is mounted on a translation stage to scan the optical element transverse to an intracavity laser beam. A performance characteristic of the laser is recorded as a function of position of the optical element.

Characterizing an optical element

A pre-printed form book includes a binding and pre-printed forms having a plurality of predetermined spaces for receiving manually written information thereon. The pre-printed form book further includes the improvement of an envelope removably attached to the binding for storage of one or more said pre-printed forms having information received thereon and having been detachably removed from the binding. The envelope, containing the detached pre-printed form with information received thereon, is pre-addressed and may be detachably removed from the binding for mailing to a remote location.

Pre-printed form book having dual purpose storage pouch and mailing

Growing community of inventors

Guilford, CT, United States of America

Faisal R Ahmad