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Università Campus Bio-Medico Di Roma

Biomedical Research in Otolaryngology Srl B.r.i.o. S.r.l.

Fabrizio Salvinelli

Manuele Casale

Paolo Soda

Valerio Cusimano

Emanuele Salvinelli

Beatrice Salvinelli

Alessandra D'Eramo

Roberto Lupo

Roberto Setola

A device for delivering a substance in the form of aerosol is described. The device is used with a syringe equipped with a plunger and without a needle. The delivery device comprises: a connection sleeve for connecting the device with the syringe; a nozzle for delivering the substance as aerosol, preferably with troncoconical walls and obtained on an elongated outer body of the device; and a fluid-dynamic path comprised between the connection sleeve and the dispensing nozzle, wherein the path comprises an annular expansion chamber and an elongated acceleration chamber, so that, while in use, a manual actuation of the plunger introduces the substance into the fluid-dynamic path in a liquid form through the connection sleeve and produces the substance as aerosol through the dispensing nozzle.

Device for delivery of an aerosol substance

The invention concerns a product consisting of distilled water or of an aqueous solution hypotonic or substantially isotonic with respect to blood plasma or, less preferably, hypertonic with respect to blood plasma, to be administered on the nasal mucosa according to a specific operation mode in order to cause an inflammation of an irritative kind, for use in a treatment of stimulation of the endogenous production of inflammatory mediators, in the therapy and prevention of neurological disorders, in particular of degenerative disorders of the central and peripheral nervous system. The inflammatory mediators the endogenous production of which is stimulated comprise NGF, neurotrophin-3, neurotrophin-4, serotonin, substance P, heparin, ECF-A.

Intranasal administration of agents with pro-inflammatory activity for the therapy of neurological disorders

A videorhinohygrometric measuring apparatus () for evaluating parameters associated to the expiratory flow outlet from the nostrils, comprising a camera () for acquiring the dynamic image of the condensation that the flow generates on a suitable collecting surface () and a processor () for the acquired image, operatively connected to the camera () and apt to output at least one of the above-mentioned entities.

Apparatus and method for videorhinohygrometric (VRI) measures

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Rome, Italy

Fabrizio Salvinelli