Swedish Orphan Biovitrum Ag

Swedish Orphen Biovitrum Ag

Fabrizio De Benedetti

Walter Ferlin

Cristina De Min

The disclosure relates generally to methods compositions and dosing regimens for treating, preventing and/or delaying the onset or progression of, or alleviating a symptom associated with elevated IFN-γ levels.

Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications

Methods and compositions for treating hemophagocytic lymphohistiocytosis (HLH) are provided. The disclosure also relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of CXCL9, elevated levels of total IFNγ, and other biomarkers. The disclosure also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of CXCL9 elevated levels of total IFNγ, and other biomarkers using agents that interfere with or otherwise antagonize interferon gamma (IFNγ) signaling, including neutralizing anti-IFNγ antibodies.

Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of CXCL9 and other biomarkers

The disclosure relates generally to methods compositions and dosing regimens for treating, preventing and/or delaying the onset or progression of, or alleviating a symptom associated with elevated IFN-&#x3b3; levels.

Methods and compositions for treating hemophagocytic lymphohistiocytosis (HLH) are provided. The disclosure also relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of CXCL9, elevated levels of total IFN&#x3b3;, and other biomarkers. The disclosure also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of CXCL9 elevated levels of total IFN&#x3b3;, and other biomarkers using agents that interfere with or otherwise antagonize interferon gamma (IFN&#x3b3;) signaling, including neutralizing anti-IFN&#x3b3; antibodies.

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Geneva, Switzerland

Fabrizio De Benedetti