Ossianix, Inc.

Spur Therapeutics Limited

Fabrizio Comper

Julia Lynn Rutkowski

Krzysztof Bartlomiej Wicher

Pawel Stocki

Jaroslaw Michal Szary

Mykhaylo Demydchuk

Carlos Miranda

The present invention relates to CD98hc binding moieties with high specificity and with ability to cross the blood brain barrier (BBB). Such moieties may be used alone or as components in specific conjugates that target the amino acid transporter complexes formed with a light chain and CD98hc. The invention relates more specifically to VNAR single chain antibodies derived from nurse shark that bind to CD98hc, compounds and compositions comprising a CD98hc-specific binding moiety, diagnostic and therapeutic methods of use in vitro or in vivo, e.g., to diagnose, treat and/or prevent a pathological condition, disorder or disease in which it is beneficial to deliver a heterologous biomolecule across the blood brain barrier by association with a CD98hc-specific VNAR binding moiety. The invention also includes Type IV semi-synthetic VNAR libraries derived from shark VNARs for selection of binding moieties that specifically bind to a molecular or cellular target of interest.

Anti-CD98hc VNARs for crossing the blood brain barrier and type IV VNAR libraries

The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier ('BBB'), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.

In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use

Growing community of inventors

Stevenage, United Kingdom

Fabrizio Comper