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Chemi S.p.a.

Fabrizio Cocchi

Lorenzo De Ferra

Maurizio Zenoni

Mauro Anibaldi

A process for the purification of L-&#x3b1;-glycerophosphorylcholine is described, wherein L-&#x3b1;-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-&#x3b1;-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-&#x3b1;-glycerophosphorylcholine is also described, comprising the elution of L-&#x3b1;-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-&#x3b1;-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

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Rome, Italy

Fabrizio Cocchi