Aventis Pharma S.a.

Sanofi

Sanofi-a Ventis Deutschland Gmbh

Novexel

Novexel Sa

Fabrice Viviani

Michel Tabart

Baptiste Ronan

Frank Halley

Eric Bacque

Catherine Souaille

Serge Mignani

Jean-Luc Malleron

Youssef El Ahmad

Michel Evers

Gilbert Marciniak

Youssef El-Ahmad

Jean-Christophe Carry

Antony Bigot

Pascal Desmazeau

Bruno Filoche-Romme

Bertrand Vivet

Laurence Gauzy-Lazo

Guy Pantel

Laurent Schio

Patrick Mailliet

Michel Cheve

Hervé Bouchard

Fabienne Thompson

Francois Clerc

Maurice Brollo

Bernard Baudoin

Marie-Pierre Cherrier

Jean-Philippe Letallec

Karl Andreas Karlsson

Philippe Hubert

Jean-Francois Nave

Annie Clauss

Eric Bacqué

St&eacute;phane Mutti

Teresa Damiano

Andre Zimmermann

Christophe Daubi&eacute;

Herve Bouchard

Marcel Patek

Martin Smrcina

Alain Jean Braun

Vincent Leroy

Anil Nair

Jean-Paul Martin

Eric Nicolai

Olivier Crespin

Cecile Pascal

Philip Janiak

Kirsten Bjergarde

Yann Foricher

Antonio Ugolini

Odile Angouillant-Boniface

Bruno Filoche-Rommé

Alain Le Brun

Mark Dodson

Nicolas Muzet

Eric Bacqu&eacute;

Eric Baque

Cécile Pascal

Martha Ackerman-Berrier

Bruno Filoche-RommÉ

André Zimmermann

Alain Braun

Jean-François Nave

The invention relates to bicyclic heterocyclic derivatives of general formula (I) to a process for preparing them and to the therapeutic use thereof. 

Pyrimidooxazocine derivatives as mTOR-inhibitors

The invention relates to compounds of the formula:  or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.

1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof

A subject-matter of the present invention is the use of compounds of formula (I) in the base, hydrate or solvate form or in the form of their mixtures, as medicaments or for the preparation of medicaments intended for the treatment of at least one cardiovascular disease and/or to prevent the appearance of at least one cardiovascular disease.

Therapeutic applications in the cardiovascular field of quinazolinedione derivatives

The invention relates to a product of formula (I) where R1, R2, R3, and R4 are as defined herein, the therapeutic use of the product, a process to make the product, and a pharmaceutical composition comprising the product.

2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof

The subject matter of the present invention is the use of compounds of formula (I) in the form of a base, a hydrate or a solvate, or of mixtures thereof, as a medicament or for preparing a medicament intended for the treatment and/or prevention of disorders associated with the central nervous system (abbreviated to CNS) and/or associated with the peripheral nervous system (abbreviated to PNS). 

Therapeutic uses of quinazolinedione derivatives

The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.

7-substituted aza-indazoles, compositions containing same, production method and use thereof

The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.

Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use

The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer agents.

Substituted pyrrolopyridines, compositions containing them, manufacturing process therefor and use thereof

The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particular as anti-cancer agents.

Substituted pyrroles, compositions containing same, method for making same and use thereof

Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents.

Substituted indoles, compositions containing them, method for the production thereof and their use

The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents.

Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof

Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.

Substituted indazoles, compositions containing the same, and the preparation and use thereof

Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology. 

[object Object]

The invention relates to 4-substituted quinoline compounds of general formula: which are active as antimicrobials, in which:

4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them

Quinolylpropylpiperidine derivatives of general formula (I) in which Ris hydrogen or fluorine, Ris carboxyl, carboxymethyl or hydroxymethyl, Ris alkyl substituted either with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkyloxycarbonyl, cyano or amino or Ris propargyl substituted by phenyl or heteroaryl as defined above and Ris alkyl, alkenyl-CH&#x2014; or alkynyl-CH&#x2014;, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents 

Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor

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Louvres, France

Fabrice Viviani