Otonomy, Inc.

University of California

Acadia Pharmaceuticals Inc.

Dompe' Farmaceutici S.p.a.

Alk-AbellÓ, Inc.

Saragovi, Horacio Uri

Fabrice Piu

Carl Lebel

Luis A Dellamary

Qiang Ye

Jay Lichter

Andrew M Trammel

Jeffrey P Harris

Benedikt K Vollrath

Michael Christopher Scaife

Sergio G Duron

Sergio G Durón

Roger Olsson

Horacio Uri Saragovi

Magnus Gustafsson

Robert Savel

Birgitte Winther Lund

Lene Hyldtoft

Hong Qi

Vladimir Sherbukhin

Zhanpeng Zhang

Mark R Brann

David M Weiner

Ethan S Burstein

Scott H Coleman

Jakob L Hansen

Andria Lee

Martha Pastuszka

Scott Coleman

Natalia Tsivkovskaia

KristenAnn Black

Bonnie Jacques

Alan Foster

Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Auris formulations for treating otic diseases and conditions

Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Triglyceride otic formulations and uses thereof

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Controlled release antimicrobial compositions and methods for the treatment of otic disorders

Auris formulations for treating OTIC diseases and conditions

Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.

Treatment using truncated Trk B and Trk C antagonists

Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

Controlled-release CNS modulating compositions and methods for the treatment of otic disorders

Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders

Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders

Growing community of inventors

San Diego, CA, United States of America

Fabrice Piu