Laboratoires Thea

Laboratories Thea

Medical University of Vienna

Fabrice Mercier

Alain Defemme

Michel Faurie

Frédéric Pilotaz

Jean-Frédéric Chibret

Henri Chibret

Frederic Pilotaz

Céline Olmiere

Emmanuel Muriaux

Celine Olmiere

Léopold Schmetterer

The invention relates to a device for dispensing an aqueous liquid through an interface membrane made partially hydrophilic and partially hydrophobic, made so that when in operation, during each operation of dispensing a metered amount of liquid, the streams of air and liquid flow alternately in a capillary channel () downstream from the membrane. Said interface membrane () is made of a filtering material which includes biocidal metal cations in the body thereof. Said device comprises a porous insert (), which is permeable both to liquid and to air, which is arranged upstream from the membrane in the path of the fluids and which is made of a material including sites with negative charges capable of attracting biocidal metal cations from said membrane.

Device for dispensing liquid from a sterile packaging bottle

Ophthalmic nutraceutical composition comprising:

Eye health composition

The invention proposes a biological protection membrane which is mounted, in a device for dispensing liquid from a sterile packaging bottle, across a fluid-circulation duct, in the path of the liquid extracted from the bottle and the outside air which is drawn into the bottle. The membrane () is made partially of a hydrophilic material and partially of a hydrophobic material. Both the hydrophobic portion () and the hydrophilic portion () are made from a polymer base, laden in the body thereof with a biocidal agent that is active in the destruction of bacteria by the ionic oxidation effect. The circulation of fluids through the membrane () is organised so as to promote the ionic action on the flow of outside air in the hydrophobic material, and to drive the ionically charged active agent by the liquid passing through the membrane in the hydrophilic portion thereof. A porous buffer (), inserted in the path of the fluids on the inside of the membrane, collects the active agent extracted from the membrane by the remaining liquid not dispensed, passing through the membrane from the outside towards the inside.

Device for dispensing liquid from a sterile packaging bottle with bi-functional membrane

The invention concerns a liquid dispenser head which is designed to be mounted on a bottle containing a liquid and comprises a filtering device () forming an interface between the inside and the outside of the bottle. The filtering device comprises tubular filters () which are extended longitudinally so they can be plunged into the bottle, particularly tubular filters whose wall consists of a membrane that is selectively permeable to a liquid to be expelled from the bottle and made of hydrophilic material for this purpose. So that the expelled liquid can be replaced by air, the membrane forming the wall of said filter tube is made of hydrophobic material so as to be selectively air-permeable. The hydrophobic membrane also filters bacteria in the air.

Liquid dispensing head, in particular for a bottle for packaging a liquid to be dispensed drop by drop

The present invention relates to a bottle for packaging a liquid to be distributed drop by drop comprising a reservoir the walls of which can be reversibly elastically deformed by letting air into the container, surmounted by a liquid dispensing head comprising a dropper nozzle protruding from the bottle and an anti-bacterial filter membrane, that is partially hydrophilic and partially hydrophobic, interposed across the path of the liquid and the air, at the base of the said nozzle. In the dispensing head, the proposal is to create the nozzle by itself out of a material containing a bactericidal agent that has the effect of preventing any bacterial growth on the surface of the said nozzle on the outside of the antibacterial membrane. A porous core is advantageously positioned inside the duct through which liquid is expelled and air is admitted.

Bottle for packaging liquid that is to be dispensed drop by drop, with antibacterial protection

The invention relates to a bottle for packaging a liquid with dropper delivery comprising a reservoir with an elastically deformable wall that can be reversed by letting air into the receptacle, surmounted by a dispensing head for the liquid comprising a drop-counting end-piece protruding to the outside of the bottle and an anti-bacterial filtering membrane, made partially hydrophilic and partially hydrophobic, which is interposed across the path of the liquid and of the air, at the base of the said end-piece. The dispensing head comprises an insert with a recessed body which contains a porous pad regulating the flow of liquid placed downstream of the reservoir and upstream of a chamber delimited downstream of the said membrane. At the base of this insert on the inner side of the bottle, longitudinal arches supporting a central pellet make star-shaped passageways radially guiding the air that enters the bottle after having passed through the porous pad.

Liquid receiving bottle with drop by drop dispensing head

Described herein is an aqueous ophthalmic solution containing an immunosuppressive agent, such as cyclosporin A, and at least three polymers. The three polymers are preferably a combination of a cellulose derivative, a polyvinyl derivative, and a macrogolglycerol hydroxystearate.

Aqueous ophthalmic solution based on cyclosporin

The present invention provides an ophthalmic solution without an antimicrobial preservative. The solution includes as an active substance at least one prostaglandin and as a solubilizing agent, a surfactant, where the solubilizing agent is polyoxyl-15-hydroxystearate.

Preservative-free prostaglandin-based ophthalmic solution

A head for dispensing liquid as a drip, includes a nozzle onto which a channel for ejecting the liquid leads. Air sucked in from the outside is returned through the channel in the opposite direction. In the nozzle, on the ejection channel, the drip dispensing head of the invention includes a valve functioning as a non-return valve for the circulation of the liquid being ejected. A mobile disc of the valve is produced so as to selectively enable air to pass through the valve when the disc is bearing against the seat thereof in a position for closing the liquid ejection channel. The disc is returned to the position by negative pressure applied upstream, which tends to suck in outside air. The disc is advantageously made of a microporous material, which provides antibacterial filtering of the return air.

Head for dispensing a liquid as a drip

This invention concerns an ophthalmic solution including:

Growing community of inventors

Clermont-Ferrand, France

Fabrice Mercier