Columbia University

Fabrice Marquet

Elisa E Konofagou

Yao-Sheng Tung

Vincent P Ferrera

Yao-Sheng Teng

Tobias Teichert

Shih-Ying Wu

Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.

Systems and methods for opening of a tissue barrier in primates

Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.

Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening

Growing community of inventors

New York, NY, United States of America

Fabrice Marquet