Lltech Management

Imagine Optic

Imagine Eyes

Fabrice Harms

Albert Claude Boccara

Bertrand Le Conte Chrestien De Poly

Xavier Levecq

Xavier Jean-François Levecq

Anne Latrive

Bertrand Le Conte De Poly

According to one aspect, the present description relates to a device for analysing a wavefront, configured to be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective comprising a pupil in a pupil plane, the analysis device comprising a two-dimensional detector comprising a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens being configured to form, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system configured to optically conjugate the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and configured to define said analysis field; a processing unit configured to determine, based on the set of images formed by the microlenses, a two-dimensional map of a characteristic parameter of the wavefront in said analysis plane.

Device for wavefront analysis and microscopic imaging systems comprising such analysis devices

A device for analysing a wavefront may be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective including a pupil in a pupil plane, the analysis device including a two-dimensional detector including a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens forming, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system optically conjugating the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and defining said analysis field; a processing unit that determines, based on the set of images formed by the microlenses, a two-dimensional map of a characteristic parameter of the wavefront in said analysis plane.

A system that includes an interference device including a reference arm on which a reflective surface is arranged, where the interference device produces, at each point of an imaging field when the sample is placed on a target arm of the interference device, interference between a reference wave and a target wave obtained by backscattering of incident light waves by means of a voxel of a slice of the sample at a given depth; an acquisition device suitable for acquiring, at a fixed path length difference between the target arm and the reference arm, a temporal series of N two-dimensional interferometric signals resulting from the interference produced at each point of the imaging field; and a processing unit that calculates an image representing temporal variations in intensity between said N two-dimensional interferometric signals.

Method and system for full-field interference microscopy imaging

The invention relates to a system () for full-field interference microscopy imaging of a three-dimensional diffusing sample (). Said system includes: &#x2014;an interference device () including a reference arm on which a reflective surface () is arranged, the interference device being suitable for producing, at each point of an imaging field when the sample is placed on a target arm of the interference device, interference between a reference wave, obtained by reflection of incident light waves onto a basic surface of the reflective surface () corresponding to said point of the imaging field, and a target wave obtained by backscattering of incident light waves by means of a voxel of a slice of the sample at a given depth, said voxel corresponding to said point of the imaging field; &#x2014;an acquisition device () suitable for acquiring, at a fixed path length difference between the target arm and the reference arm, a temporal series of N two-dimensional interferometric signals resulting from the interference produced at each point of the imaging field; and &#x2014;a processing unit () configured to calculate an image (IB, IC) representing temporal variations in intensity between said N two-dimensional interferometric signals.

A device for three-dimensional imaging by full-field interferential microscopy of a volumic and scattering sample includes an imaging interferometer of variable magnification, allowing for the acquisition of at least one first and one second interferometric images resulting from the interference of a reference wave obtained by reflection of the incident wave on a reference mirror and an object wave obtained by backscattering of the incident wave by a slice of the sample at a given depth of the sample. The invention also relates to a processing unit that processes the interferometric images, a unit for axially displacing the interferometer relative to the sample for the acquisition of tomographic images for slices at different depths of the sample, and a unit for varying the magnification of the imaging interferometer for the acquisition of interferometric images of a slice for different magnification values.

Method and device for high resolution full field interference microscopy

According to a first aspect, the invention relates to a multimodal optical sectioning microscope () for full-field imaging of a volumic and scattering sample comprising: &#x2014;a full-field OCT system for providing an image of a first section in depth of the sample comprising an illumination sub-system () and a full-field imaging interferometer with a detection sub system () and an optical conjugation device for optically conjugating the sample and said detection sub system, wherein said optical conjugation device comprises a microscope objective (), &#x2014;a supplementary full-field optical sectioning imaging system for providing a fluorescent image of a second section in depth of said sample comprising a structured illumination microscope with an illumination sub system (), means () for generating at the focal plane of said microscope objective of said full-field imaging interferometer a variable spatial pattern illumination and a detection sub system (), optically conjugated with said focal plane of the microscope objective.

Optical tissue sectioning using full field optical coherence tomography

The present invention relates to a full-field optical coherence tomography system () for imaging an object (), comprising a light source (), a first interferometric device having means for splitting an input light beam and comprising at least a reflecting surface (), a second interferometric device having means for splitting the spectrally modulated output beam and comprising at least a reflecting surface, a multichannel acquisition device (), the system () being characterized in that at least one of the interferometric devices includes at least a focusing optical element arranged to focus at least one of the input beams or at least one of the output beams onto the corresponding reflecting surface of the corresponding interferometric device.

Full-field optical coherence tomography system for imaging an object

The invention relates to an incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample (). The device comprises an interference device () between a reference wave (), produced by reflection of an incident wave by a reflective surface () of a reference arm of the interference device, and an object wave () produced by backscattering of the incident wave by a slice of the sample, an acquisition device () for at least a first interference signal and at least a second interference signal resulting from the interference of the reference and object waves, the at least two interference signals having a phase difference, an processing unit () for calculating an image of the slice of the sample, based on said interference signals. The interference device also comprises an optical element () for modifying the phase of the wavefront, and the microscopy device comprises a control unit () for the optical element, linked to the processing unit (), the optical phase modification element being controlled by optimizing a statistical parameter of at least a part of the image calculated by the processing unit.

A method for measuring, in a given plane, the scattering of an optical system, including:

Method and device for measuring the local scattering of an optical system

A wavefront analysing device, of the Hartmann or Shack-Hartmann type, comprises in particular a set of sampling elements arranged in an analysis plane, and forming as many micro-lenses for sampling the incident wavefront, and a diffraction plane wherein are analysed the Airy discs of the different micro-lenses illuminated by the incident wavefront. The shape of each micro-lens is such that the associated diffraction figure has in the diffraction plane one or several preferential axe(s), and the microlenses are oriented in the analysis plane such that the preferential axe(s) of the diffraction figure of a micro-lens are offset relative to the preferential axes of the diffraction figures of neighbouring micro-lenses, thereby enabling to limit the overlapping of the diffraction figures.

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Orsay, France

Fabrice Harms