Croda International, Inc.

Fabrice Berrué

Russell Greig Kerr

David Patrick Overy

Bradley Arnold Haltli

Douglas Hubert Marchbank

Surfactants based on a newly discovered class of compounds include a hydrophobic lipid oligomer covalently linked to a peptide or peptide-like chain and a carbohydrate moiety, and a serine-leucinol dipeptide linked to the lipid oligomer. Such surfactants can be used to create an oil-in-water or water-in-oil emulsion by mixing together a polar component; a non-polar component; and the surfactant. Biosurfactants of the newly discovered class can be made by isolating and culturing a microorganism which produces the biosurfactant, and then isolating the biosurfactant from the culture. A microorganism can be engineered to produce biosurfactant of this newly discovered class by expressing a set of heterologous genes involved in the biosynthesis of the biosurfactant in the microorganism.

Glycolipopeptide biosurfactants

Use of pycnidione, epolone A, and epolone B as anti-dandruff actives either alone or in combination in anti-dandruff compositions, particularly shampoos and conditioners. The actives are particularly effective againstyeasts and. A method of obtaining pycnidione, epolone A, and epolone B from culturing ofis also described.

Anti-dandruff composition comprising pycnidione and epolone

Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective againstyeasts andwhich may cause dandruff. A method of obtaining the anti-dandruff actives from culturing ofsp. strain RKDO347 is also described.

Anti-dandruff compositions comprising a spirofuranone lactam tetramic acid derivative

A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective againstyeasts andwhich may cause dandruff. A method of obtaining the fumagillin derivative from culturing ofsp. strain RKDO347 is also described. 

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Halifax, Canada

Fabrice Berrué