Quantum Genomics

Other

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

College De France

Inserm

Fabrice Balavoine

Jean-Marie Schneider

Nicolas Couvrat

Gérard Coquerel

Catherine Llorens-Cortes

Yannick Marc

Delphine Compere

Jonathan Madec

Patrick Schultz

Yohann Cartigny

Gerard Coquerel

Charles Mioskowski

Marie-Noelle Petit

Marie-Noëlle Petit

Mathilde Keck

Cyrille Richard

Charles Miokowski

Lionel Segard

Ji Gao-Desliens

Solène E Boitard

The present invention relates to compounds, to compositions comprising the same, to methods for preparing the compounds, and the use of these compounds in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

Compounds and compositions comprising the same for treating hypertension or heart failure

The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

Aminopeptidase A inhibitors and pharmaceutical compositions comprising the same

The present invention relates to a pharmaceutical composition comprising, in at least one pharmaceutically acceptable support or vehicle, a combination of (3S,3S')4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) or a pharmaceutically acceptable salt or solvate thereof and a second active ingredient selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type I antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.

Combination of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent

The present invention relates to a new crystalline phase of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S&#x2032;) 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.

Crystalline phase of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine

The present invention relates to a new method for the preparation of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.

Method for the preparation of (3S,3S') 4,4&#x2032;-disulfanediylbis (3-aminobutane 1-sulfonic acid)

Crystalline phase of (3S.3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine

Method for the preparation of (3S, 3S') 4,4&#x2032;-disulfanediylbis (3-aminobutane 1-sulfonic acid)

Method for immobilizing and/or crystallizing biological macromolecules on carbon nanotubes and uses

The invention concerns molecular rods, their uses in a method for fixing and/or crystallising macromolecules, the resulting products and uses of said products in the field of materials and structural biology, in particular as biosensors or as biomaterials. Said molecular rods have a structure represented by the general formula (I) and said method essentially consists in incubating, for at least 15 minutes, a biological macromolecule in solution with a molecular rod as defined by the formula, in suitable temperature and pH conditions.

Molecular rod and uses

Growing community of inventors

Paris, France

Fabrice Balavoine